2009 Fiscal Year Final Research Report
Augmented anti-arthritic effect of soluble RAGE tagged with an acidic oligopeptide
| Project/Area Number |
20790150
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Hokuriku University |
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Principal Investigator |
TAKAHASHI Tatsuo Hokuriku University, 薬学部, 助教 (50445904)
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| Project Period (FY) |
2008 – 2009
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| Keywords | ドラッグデリバリー / 関節リウマチ / 可溶型RAGE / 酸性オリゴペプチド |
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| Research Abstract |
Endogenous secretory receptor for advanced glycation endproducts (esRAGE) can act as decoy receptor of HMGB1 involved in progression of rheumatoid arthritis. Tagging with an acidic oligopeptide (AcOP), bone-targeting carrier, was enable to augment bone distribution of esRAGE, while retaining function as decoy receptor. Moreover AcOP-tagged esRAGE retained in bone at least one week after intravenous injection. In rheumatoid arthritis model mice, weekly injection of AcOP-tagged esRAGE attenuated swelling of four limbs more effectively than untagged esRAGE. Thus bone-targeting system with an acidic oligopeptide is applicable to esRAGE as potential agent of rheumatoid arthritis.
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