2009 Fiscal Year Final Research Report

Clarification of the mechanism of the hypersensitivity induced by the antineoplastic agent paclitaxel and identification of a prophylactic agent for this hypersensitivity

Research Project

Project/Area Number	20790154
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Medical pharmacy
Research Institution	Fukuyama University
Principal Investigator	GOROMARU Takeshi Fukuyama University, 薬学部, 講師 (70412319)
Project Period (FY)	2008 – 2009
Keywords	医薬品 / 副作用 / 過敏反応
Research Abstract	Paclitaxel-induced hypersensitivity is thought to be caused by the solvent Cremophor EL. We studied the hypersensitivity responses in rats that received 3 paclitaxel formulations prepared using different solvents. The levels of hypersensitivity to the 3 formulations were not significantly different. These findings suggest that paclitaxel-induced hypersensitivity is caused not by the solvent, but by the active ingredient of the formulation. In addition, ibudilast was found to attenuate the paclitaxel-induced pulmonary vascular hyperpermeability. We found that ibudilast was useful for prophylaxis against paclitaxel-induced hypersensitivity.

(4 results)