2010 Fiscal Year Final Research Report
Analysis for Phagocytosis in mice lacking vesicular associated membrane protein-7 (VAMP7)
| Project/Area Number |
20790159
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Gunma University |
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Principal Investigator |
SATO Mahito Gunma University, 大学院・医学系研究科, 助教 (60375532)
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| Project Period (FY) |
2008 – 2010
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| Keywords | マクロファージ / 異物貪食 / 遺伝子欠失マウス |
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| Research Abstract |
Phagocytosis by macrophages plays important roles in immune response to microbes. In this study, we investigated the molecular mechanisms of phagocytosis by using mice lacking the VAMP7 gene, which regulate vesicular trafficking. The results show the possible roles of VAMP7 in phagocytosis and phagosome-lysosome fusion in macrophages through some specific pathways. However, we also revealed that VAMP7 does not regulate immune response to malaria. The physiological roles of VAMP7 are still to be investigated.
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