2009 Fiscal Year Final Research Report
The analysis of molecular mechanism of Caudal Regression Syndrome (CRS)
| Project/Area Number |
20790163
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Kumamoto University |
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Principal Investigator |
SUZUKI Kentaro Kumamoto University, 発生医学研究所 (20404345)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 先天異常学 / 奇形学 / 尾部退行症候群(人魚病) / 増殖因子 |
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| Research Abstract |
Caudal regression syndrome (CRS) comprises developmental anomalies of the caudal vertebrae, urogenital organs and hind limbs. The mermaid like phenotypes has been often described in many literatures including old legends. However, the pathogenetic mechanisms are not understood. This study suggested that Bmp4, one of the Bmp ligands, may be essential molecule to make the caudal body with regulating the expression of patterning genes.
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