2011 Fiscal Year Final Research Report
Evolution of podocyte and primary urine-producing organs
| Project/Area Number |
20790166
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2011
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| Keywords | 比較解剖学 / 比較細胞組織学 / 比較細胞生物学 / 腎臓学 |
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| Research Abstract |
Mammals and birds possess high-performance primary-urine producing apparatus(renal glomerulus) by virtue of their high blood pressure. However, the protection mechanisms of glomerular structure from the high intraglomerular pressure and fluid shear stress remain poorly understood. In this study, we found that primary cilium, which is one of the fluid mechanosensors, disappeared from the glomerular podocytes in mammalian and bird metanephros. The primary cilia on the podocytes are subjected to a stronger bending force in mammals and birds. Thus the disappearance of the primary cilia presumably prevents the entry of excessive calcium-ion via the cilium-associated calcium channels and the disturbance of intracellular signaling cascades in podocytes.
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