2010 Fiscal Year Final Research Report
A novel molecular complex formed by paracellin-1 involved in the regulation of magnesium reabsorption
| Project/Area Number |
20790175
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | University of Shizuoka |
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Principal Investigator |
IKARI Akira University of Shizuoka, 薬学部, 准教授 (50315850)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 生体膜 / チャネル / マグネシウム / 細胞接着 / 腎臓 / パラセリン-1 |
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| Research Abstract |
Magnesium ion is reabsorbed in the renal tubule. The transport pathway and regulatory mechanisms of magnesium reabsorption have not been clarified yet. We found that paracellin-1 is distributed at the tight junction and regulates a paracellular magnesium transport. The intracellular distribution of paracellin-1 was regulated by the formation of complexes with various phosphorylated proteins. Magnesium deficiency induces cardiovascular diseases such as hypertension and arrhythmia. To avoid magnesium deficiency, the magnesium reabsorption is rigorously controlled by the paracellin-1 complexes.
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