2010 Fiscal Year Final Research Report
The regulatory mechanism of claudins for paracellular pathway of the human amniotic epithelium.
| Project/Area Number |
20790177
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Keio University |
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Principal Investigator |
KOBAYASHI Ken Keio University, 大学院・農学研究院, 助教 (30449003)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 羊膜 / タイトジャンクション / クローディン / 羊水 / 傍細胞経路 / 絨毛膜羊膜炎 |
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| Research Abstract |
The amniotic epithelium is in direct contact with the amniotic fluid and regulates fluid flux via paracellular pathway by tight junctions. In this study, we investigated the regulatory mechanism of tight junctions and claudins as the basic research for premature birth and chorioamnionitis. The results have been shown that several physiological active substances such as hormone and inflammatory cytokines regulate the permeability of amniotic tight junctions through claudins.
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