2009 Fiscal Year Final Research Report
Regulation of physiological functions by magnesium ions in white adipocytes
| Project/Area Number |
20790179
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
INOUE Hana Tokyo Medical University, 医学部, 助教 (20390700)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 分子 / 細胞生理学 |
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| Research Abstract |
In the present study, we have established the methods to prepare white adipocytes suitable for various physiological experiments. In this preparation, it was clarified that the volume-sensitive chloride channel is expressed and involved in volume regulation in white adipocytes. Expression level of this channel was decreased in white adipocytes from diabetic animals. Moreover, it was also revealed that white adipocytes express MIC channel which is regulated by both intracellular and extracellular magnesium ions.
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