2010 Fiscal Year Final Research Report

Involvement of concentration-sensitive sodium channel in alveolar fluid clearance

Research Project

Project/Area Number	20790183
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	General physiology
Research Institution	Kinki University
Principal Investigator	HAGIWARA Teruki Kinki University, 理工学部, 助教 (70411577)
Project Period (FY)	2008 – 2010
Keywords	炎症 / ナトリウムチャネル / 急性肺障害 / Lung fluid clearance
Research Abstract	Physiological roles of concentration-sensitive sodium channels (Na_C : c=concentration) expressed in mouse alveolar epithelial cells are not yet known. In this study, we investigated the role of Na_C in alveolar fluid clearance. Na_C expression dramatically decreased in the lung during inflammation induced by lipopolysaccharide. Lung fluid content increased during early inflammation and decreased after the recovery of Na_C expression. These results suggested that LPS-induced suppression of Na_C in alveolar epithelial cells reduced AFC and caused the increase in lung fluid content in acute lung injury.