2009 Fiscal Year Final Research Report

Physiological analysis of novel orphan GPCR involved in energy homeostasis

Research Project

Project/Area Number	20790187
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	General physiology
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	SANO Takamitsu The Institute of Physical and Chemical Research, 神経膜機能研究チーム, 客員研究員 (10399967)
Project Period (FY)	2008 – 2009
Keywords	GPCR / エネルギーホメオスタシス / 肥満
Research Abstract	Drosophila orphan GPCR, bride of sevenless (BOSS) responds to extracellular glucose and regulates sugar and lipid metabolism. BOSS is evolutionally conserved from fly to human. In mammal, four homologues of BOSS, GPRC5A, GPRC5B, GPRC5C, and GPRC5D, exist. However, their molecular and physiological functions remain unclear. Here, we describe the role of GPRC5B in the regulation of energy homeostasis. GPRC5B was expressed highly in the brain and adipose tissue. GPCR5B-deficient mice showed decreased weight gain compared with wild type mice, despite of the similar food intake. This phenotype was attributed to increased oxygen consumption, but not increased physical activity.