2009 Fiscal Year Final Research Report
Analysis of coupling mechanism of voltage-gated H^+ channel and NADPH oxidase
| Project/Area Number |
20790189
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Osaka University |
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Principal Investigator |
OKOCHI Yoshifumi Osaka University, 医学系研究科, 助教 (90435818)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 電位依存性プロトンチャネル / 好中球 / 活性酸素 / NADPHオキシダーゼ |
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| Research Abstract |
We found that voltage-gated proton channel, VSOP, regulates reactive oxygen species (ROS) generation in neutrophils, which have the ability of killing pathogens. We also found the possibility that VSOP and NADPH oxidase interact physically and that both molecules are present in same location of neutrophils. These results suggest that VSOP can regulate intracellular/extracellular proton and membrane potential properly by interaction with NADPH oxidase and then regulate ROS generation.
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