2010 Fiscal Year Final Research Report
Spinal and supraspinal mechanisms of muscular nociception in a rat model of delayed onset muscle soreness.
| Project/Area Number |
20790191
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Nagoya University |
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Principal Investigator |
TAGUCHI Toru Nagoya University, 環境医学研究所, 助教 (90464156)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUMURA Kazue 名古屋大学, 環境医学研究所・神経系分野II, 教授 (00109349)
MENSE Siegfried ハイデルベルグ大学, 医学部・マンハイム・CBTM・神経解剖学, 教授
HOHEISEL Ulrich ハイデルベルグ大学, 医学部・マンハイム・CBTM・神経解剖学, 研究員
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| Project Period (FY) |
2008 – 2010
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| Keywords | 筋性疼痛 / 遅発性筋痛 / 加齢 / 脊髄 / 侵害受容器 / 機械受容 |
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| Research Abstract |
Clarified the involvement of transient receptor potential(TRP)channels and acid-sensing ion channels in muscular mechanical hyperalgesia in delayed onset muscle soreness (DOMS). 2) Demonstrated crucial roles of bradykinin B2 receptor activation and nerve growth factor in DOMS. 3) Showed the higher sensitivity to noxious stimulation in the fascia than the exercised muscle itself in DOMS. 4) Clarified that the mechanical sensitivity of muscular C-fiber nociceptors increased as a function of age while that of cutaneous nociceptors decreased. 5) Clarified the spinal mechanisms of low back pain originating from low back muscles and fasciae by the extracellular recording of the spinal dorsal horn neurons. 6) Quantified the release of ATP from the skeletal muscle by compression. 7) Developed an animal model of chronic muscle pain by repeated cold stress in rats. 8) Suggested the existence of a novel receptor specific to acromelic acid-A (ACRO-A at the nociceptor endings by demonstrating that a half of mechano-sensitive C-fibers in the muscle excited by ACRO-A.
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[Journal Article] Bradykinin and nerve growth factor play pivotal roles in muscular mechanical hyperalgesia after exercise (delayed onset muscle soreness).2010
Author(s)
Murase S, Terazawa E, Queme F, Ota H, Matsuda T, Hirate K, Kozaki K, Katanosaka K, Taguchi T, Urai H, Mizumura K.
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Journal Title
J Neurosci 30
Pages: 3752-3761
Peer Reviewed
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[Presentation] 筋性疼痛におけるNGF(神経成長因子)の役割2009
Author(s)
Murase S, Taguchi T, Matsuda T, Queme F, Urai H, Katanosaka K, Mizumura K.
Organizer
第31回日本疼痛学会
Place of Presentation
名古屋(シンポジウム)
Year and Date
20090716-20090718
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