2009 Fiscal Year Final Research Report
Proliferation and differentiation of neuronal progenitor cells in the hypothalamus of heat-exposed rats
| Project/Area Number |
20790192
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Shimane University |
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Principal Investigator |
MATSUZAKI Kentaro Shimane University, 医学部, 助教 (90457185)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 生理学 / 神経科学 / 体温調節 / 暑熱馴化 / 神経新生 |
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| Research Abstract |
Immunohistochemical analysis showed that the numbers of BrdU-positive cells in the hypothalamus of heat-exposed rats (HE) were significantly and consistently greater than those of control rats (CN). In HE, the number of BrdU-positive cells double-stained by a mature neuron marker increased abruptly after 33 days of heat exposure by about 7 times. This was not the case in CN. The results suggest that heat exposure facilitates proliferation of neuronal progenitor cells in the hypothalamus and promotes differentiation to neurons, which might be have certain relation to establishing long-term heat acclimation in rats.
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