2009 Fiscal Year Final Research Report
WANIAR4 ( M) Development of the animal model for postpartum psychosis and the elucidation of pathogenic mechanisms through estrogen action
| Project/Area Number |
20790198
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | St.Marianna University School of Medicine |
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Principal Investigator |
NAGATANI Miyako St.Marianna University School of Medicine, 医学部, 助教 (20450611)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 生殖生理学 |
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| Research Abstract |
We found that primiparous rats at 3 weeks-postpartum showed increased anxiety and depressive behaviors in elevated plus maze (EP) and forced swimming (FS) tests, compared with diestrus nulliparous females. ERa-selective agonist and estrogen displayed anxiolytic and antidepressant effects in EP and FS tests at 3 weeks-postpartum after subcutaneous injection once daily for 4 days. Furthermore, we found a marked alteration in the expression of TrkB and BDNF (brain-derived neurotrophic factor) receptors, and in resultant intracellular signaling of the 3 weeks-postpartums. This raises a possibility that changes of neurotrophin signaling via ERa stimulation are associated with anxiety and depression-like behaviors. In couclusion, we identified an animal model of postpartum psychosis and postpartum depression, which could be employed to develop innovative drugs of ERa stimulant for these diseases.
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