2009 Fiscal Year Final Research Report
Role of inositol 1, 4, 5-trisphosphate in the maintenance of the function of cerebellar Bergmann glia
| Project/Area Number |
20790202
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKUBO Yohei The University of Tokyo, 大学院・医学系研究科, 助教 (40422282)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 中枢・末梢神経 / 脳・神経 / プルキンエ細胞 / バーグマングリア / カルシウ / IP3 |
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| Research Abstract |
Synapse is a connecting point between neurons. The maintenance of synaptic functions is essential for stable neuronal information processing in the adult brain. Bergmann glial cells express glutamate transporters that rapidly remove glutamate from the extracellular space, and play a critical role in the precise operation of synaptic transmission in the cerebellum. We found that a signaling cascade comprising inositol 1,4,5-trisphosphate is involved in glutamate transporter expression to maintain the capacity of glutamate clearance. Thus, inositol 1,4,5-trisphosphate is essential for the maintenance of synaptic function.
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Research Products
(10 results)
