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2010 Fiscal Year Final Research Report

Regulation of dendritic voltage gated ion channels by neurotransmitters.

Research Project

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Project/Area Number 20790211
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionKeio University

Principal Investigator

NURIYA Mutsuo  Keio University, 医学部, 講師 (60453544)

Project Period (FY) 2008 – 2010
Keywords神経伝達物質 / 電位依存性チャネル / 翻訳後修飾 / 神経細胞
Research Abstract

In this study, regulations of voltage gated ion channels in neurons, which are considered to play key roles in neuronal physiology, were studied. Pharmacological investigations revealed that these channels are regulated by neuronal activity, which in turn contribute to the maintenance of their activities. In addition, a novel microscopy technique that allows investigation of neuronal activities has been developed and applied to reveal the nature of voltage information processing in axons. Therefore, this study revealed new cellular mechanisms by which neurons maintain their overall activities and also provided a new microscopic technique that can be applied to future physiological researches.

  • Research Products

    (16 results)

All 2010 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (13 results)

  • [Journal Article] Membrane potential dynamics of axons in cultured hippocampal neurons probed by second harmonic generation imaging.2010

    • Author(s)
      Nuriya M, Yasui M.
    • Journal Title

      Journal of Biomedical Optics. 15(2)

      Pages: 020503

    • Peer Reviewed
  • [Journal Article] Regulation of Kv2.1 phosphorylation in an animal model of anoxia.2010

    • Author(s)
      Ito T, Nuriya M, Yasui M.
    • Journal Title

      Neurobiology of Disease. 38(1)

      Pages: 85-91

    • Peer Reviewed
  • [Journal Article] Activity-dependent regulation of HCN1 protein in cortical neurons.2009

    • Author(s)
      Arimitsu T, Nuriya M, Ikeda K, Takahashi T, Yasui M.
    • Journal Title

      Biochem Biophys Res Commun. 387(1)

      Pages: 87-91

    • Peer Reviewed
  • [Presentation] Imaging Membrane Potential Dynamics in Fine Structures using Second Harmonic Generation Imaging2010

    • Author(s)
      Mutsuo Nuriya
    • Organizer
      Light in Life Science Conference
    • Place of Presentation
      東京
    • Year and Date
      2010-12-01
  • [Presentation] 第二高調波イメージングを用いた神経細胞情報伝達機構の解析2010

    • Author(s)
      塗谷睦生
    • Organizer
      第31回日本レーザー医学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-14
  • [Presentation] 第二高調波イメージングを用いた培養海馬神経細胞の軸索における電位情報伝達の解析2010

    • Author(s)
      塗谷睦生、安井正人
    • Organizer
      第48回生物物理学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-20
  • [Presentation] 第二高調波イメージングを用いた神経細胞細部における電位情報伝達の解析2010

    • Author(s)
      塗谷睦生
    • Organizer
      日本バイオイメージング学会第19回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-09
  • [Presentation] Biochemical and Optical Analyses of Membrane Potential Dynamics in Neurons2010

    • Author(s)
      Mutsuo Nuriya
    • Organizer
      Fifth International Neural Microcircuitry Conference
    • Place of Presentation
      東京
    • Year and Date
      2010-06-30
  • [Presentation] Imaging Membrane Potential Dynamics in Fine Structures using Second Harmonic Generation Imaging2009

    • Author(s)
      Mutsuo Nuriya
    • Organizer
      Light in Life Science Conference
    • Place of Presentation
      オーストラリア
    • Year and Date
      2009-11-26
  • [Presentation] Electrical Signaling in Dendrites Probed by Second Harmonic Generation Imaging2009

    • Author(s)
      Mutsuo Nuriya
    • Organizer
      The 32nd Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-16
  • [Presentation] Imaging Membrane Potential Dynamics in Fine Structures using the Second Harmonic Generation Imaging2009

    • Author(s)
      Mutsuo Nuriya
    • Organizer
      International Congress of Physiological Sciences (IUPS 2009)
    • Place of Presentation
      京都
    • Year and Date
      2009-08-01
  • [Presentation] Imaging Membrane Potential Dynamics in Dendrites using Second Harmonic Generation Imaging2009

    • Author(s)
      Mutsuo Nuriya
    • Organizer
      International Symposium "Topical Problems of Biophotonics-2009"
    • Place of Presentation
      ロシア
    • Year and Date
      2009-07-23
  • [Presentation] NMDA 型グルタミン酸受容体活性によるKv4.2カリウムチャネルの制御2009

    • Author(s)
      塗谷睦生、伊藤尚志、安井正人
    • Organizer
      第82回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-03-16
  • [Presentation] Second Harmonic Generation (SHG)イメージングによる定量的膜電位計 測2008

    • Author(s)
      塗谷睦生
    • Organizer
      第46回生物物理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2008-12-04
  • [Presentation] Regulation of Kv4.2 by Neuronal Activity.2008

    • Author(s)
      Mutsuo Nuriya, Takashi Ito, Anne E.Anderson, Masato Yasui
    • Organizer
      北米神経科学会年会
    • Place of Presentation
      アメリカ合衆国
    • Year and Date
      2008-11-16
  • [Presentation] 多光子励起レーザ走査顕微鏡が切り拓く新しいイメージングの世界2008

    • Author(s)
      塗谷睦生
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10

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Published: 2012-02-13   Modified: 2016-04-21  

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