2009 Fiscal Year Final Research Report
Role of cation transporter in the regulation of macrophage function.
| Project/Area Number |
20790215
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Fukuoka University |
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Principal Investigator |
IYODA Takuya Fukuoka University, 医学部, 助教 (80465715)
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| Project Period (FY) |
2008 – 2009
|
| Keywords | アルドステロン / 心障害 / 炎症・免疫 |
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| Research Abstract |
Recent studies have indicated the utility of mineralocorticoid receptor antagonist in cardiovascular injuries. Actually, chronic treatment with aldosterone can induce several pathological features, including cardiac hypertrophy, in experimental animals. In this study, we showed that NCX1 would be implicated in the progression of aldosterone-induced cardiac remodeling in experimental model of hyper-aldosteronism. These results suggest that NCX1 inhibitors might be useful for heart failure therapeutically.
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Research Products
(12 results)
