Regulation of stem cell proliferation by Tsc-22

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790220
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: University of Tsukuba
• Principal Investigator: SUZUKI Hiroyuki University of Tsukuba, 大学院・人間総合科学研究科, 助教 (70375509)
• Project Period (FY): 2008 – 2009
• Keywords: Tsc-22 / c-Myc / Oct4 / Eras / 幹細胞 / 転写因子 / 癌 / p21

Research Abstract

Tsc-22 inhibits ES cell proliferation with maintaining the pluripotency. By analyzing the transcriptional factors that interact with Tsc-22 among Yamanaka factors (Oct4, c-Myc, Klf4 and Sox2), we found that Tsc-22 interacts c-Myc and Oct4. Tsc-22 suppresses the c-Myc/Oct4-mediated inhibition of p21 promoters. Furthermore, Tsc-22 interacts with ERas and inhibits PI3 kinase-Akt pathway.

Research Products

• [Journal Article] TGF-β, 間接リウマチ (2010)
  • Author(s): 鈴木裕之、青山知恵、加藤光保
  • Journal Title: 日本臨床
• [Journal Article] Protein kinase C-dependent upregulation of miR-203 induces the differentiation of human keratinocytes. (2010)
  • Author(s): Sonkoly E, Wei T, Lorie EP, Suzuki H, Kato. M, Torma H, Stahle M, Pivarcsi A
  • Journal Title: J Invest Dermatol. 130 Pages: 124-34
  • Peer Reviewed
• [Journal Article] Roles of mono-ubiquitinated Smad4 in the formation of Smad transcriptional complexes. (2008)
  • Author(s): Wang B, Suzuki H (corresponding author), Kato M.
  • Journal Title: Biochem Biophys Res Commun. 376 Pages: 288-292
  • Peer Reviewed
• [Journal Article] Tristetraprolin (TTP) gene polymorphisms in patients with rheumatoid arthritis and healthy individuals. (2008)
  • Author(s): Suzuki T, Tsutsumi A, Suzuki H, Suzuki E, Sugihara M, Muraki Y, Hayashi T, Chino Y, Goto D, Matsumoto I, Ito S, Miyazawa K, Sumida T
  • Journal Title: Mod Rheumatol 18 Pages: 472-479
  • Peer Reviewed
• [Journal Article] TGF-βシグナル伝達と癌治療 (2008)
  • Author(s): 鈴木裕之、中条友香、加藤光保
  • Journal Title: がんの分子標的治療(南山道) Pages: 132-139
• [Presentation] Tsc-22 inhibits cellular proliferation through regulation of c-Myc and Oct4 (2010)
  • Author(s): Suzuki H, Nakajo Y, Nakano A, Nakayama. Y, Kato M
  • Organizer: AACR/JCA Joint Conference
  • Place of Presentation: Waikoloa, Hawaii
  • Year and Date: 2010-02-05
• [Presentation] Regulation of cellular proliferation by transforming growth factor-b stimulated clone 22 (2009)
  • Author(s): Suzuki H, Nakano A, Kato M
  • Organizer: 68th Annual meeting
  • Place of Presentation: Japanese Cancer Association
  • Year and Date: 2009-10-01
• [Presentation] Promotion of colony dispersion and cell motility by cooperative action of TGF-βand EGF signaling (2009)
  • Author(s): Suzuki H, Tozuka R, Kato M
  • Organizer: 98th Annual meeting of the Japanese Society of Pathology
  • Place of Presentation: Oral in Japanese
  • Year and Date: 2009-05-03
• [Remarks]
  • URL: http://www.md.tsukuba.ac.jp/epatho/