2009 Fiscal Year Final Research Report
Functional analysis of novel lipid-metabolizing enzymes belonging to the NlpC/p60 family
| Project/Area Number |
20790231
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Kagawa University |
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Principal Investigator |
UYAMA Toru Kagawa University, 医学部, 助教 (30457337)
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| Project Period (FY) |
2008 – 2009
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| Keywords | H-rev107 / HRASLSファミリー / 癌抑制遺伝子 / グリセロリン脂質 / ホスホリパーゼA1 / ホスホリパーゼA2 / アシル転移酵素 / レシチン・レチノール・アシル転移酵素 |
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| Research Abstract |
We investigated possible lipid-metabolizing activities of HRASLS family members which were originally identified as tumor suppressor genes. H-rev107, HRASLS2 and TIG3, which are included in the HRASLS family members, showed lipid-metabolizing activities using glycerophospholipids as substrate. PCR analysis revealed that H-rev107 and TIG3 are expressed in all the tissues examined, with the highest expression of H-rev107 in adipose tissue. On the other hand, the expression of HRASLS2 was dominant in liver and kidney with low levels in other tissues.
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