2009 Fiscal Year Final Research Report
Identification and characterization of a new ligand of BLT2
| Project/Area Number |
20790232
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
OKUNO Toshiaki Kyushu University, 大学院・医学研究院・医化学分野, 助教 (60361466)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | 生理活性脂質 / 受容体 |
|---|
| Research Abstract |
I found that 12-hydroxy-heptadeca-trienoic acid (12-HHT) is a natural ligand for BLT2, which was originally identified as a low-affinity leukotriene B4 receptor. From analyses of BLT2 deficient mice, we found that BLT2 is involved in inflammatory bowel disease, and we found that helix 8 of BLT2 C-teriminal is involved in receptor trafficking to the plasma membrane.
|
