2009 Fiscal Year Final Research Report

Regulation of cell polarity by a novel Par3-binding protein

Research Project

Project/Area Number	20790233
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	General medical chemistry
Research Institution	Kyushu University
Principal Investigator	KAMAKURA Sachiko Kyushu University, 生体防御医学研究所, 助教 (80398081)
Project Period (FY)	2008 – 2009
Keywords	細胞内シグナル伝達
Research Abstract	Cell polarization is crucial for a variety of processes in development. The Par3/Par6/aPKC (Par aPKC) complex is required for polarity establishment in several types of cell. During the process, the Par aPKC complex is targeted to the plasma membrane, which plays an important role in cell polarization. However, little is known about the mechanisms underlying proper subcellular localization of the complex. In the present study, we identify a novel Par3-binding protein, which recruits the Par aPKC complex to the plasma membrane for regulating mammalian epithelial cell polarity.