2009 Fiscal Year Final Research Report
The establishment of the induced pluripotent stem cells (iPS cells) from wild type mouse somatic cells
| Project/Area Number |
20790235
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Saitama Medical University |
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Principal Investigator |
MITSUI Kaoru Saitama Medical University, 大学院・医歯学総合研究科, 講師 (40324975)
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| Project Period (FY) |
2008 – 2009
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| Keywords | iPS細胞 / ウイルスベクター |
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| Research Abstract |
In order to generate safety induced pluripotent stem cells (iPS cells), two chromosome non-integration viral vectors infected to murine embryonic fibroblasts or human fibroblasts. However, I did not demonstrated successful reprogramming of any fibroblasts under culture conditions necessary for induction of iPS cells. In addition, I attempted to generate adenoviral vectors, which specifically expressed in undifferentiated state.
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