2009 Fiscal Year Final Research Report
Prediction of metabolic dynamics in human erythrocytes based on a large-scale mathematical model and its verification by metabolome analysis
| Project/Area Number |
20790237
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Keio University |
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Principal Investigator |
YACHIE Ayako Keio University, 医学部, 助教 (10453549)
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| Project Period (FY) |
2008 – 2009
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| Keywords | システム生物学 / シミュレーション / 血液保存 / メタボローム / 代謝解析 |
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| Research Abstract |
Large-scale mathematical model of metabolism in human red blood cells predicted that high extracellular adenosine resulted in decrease in intracellular ATP levels, and that the reduction of cellular energy would be compensated by glycolytic activation through hypoxia-induced hemoglobin-transition. A simulation model that can reproduce the metabolic behavior in long and cold stored red blood cells in MAP solution was also developed. The MAP-stored model would contribute to high-throughput and low-cost screening of optimized stored condition.
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