2009 Fiscal Year Final Research Report

The analysis of Drosophila WNK, the causative gene of PHA2.

Research Project

Project/Area Number	20790249
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Pathological medical chemistry
Research Institution	Tokyo Medical and Dental University
Principal Investigator	SATO Atsushi Tokyo Medical and Dental University, 難治疾患研究所, 特任助教 (30451925)
Project Period (FY)	2008 – 2009
Keywords	WNK / 偽性低アルドステイン症 / ショウジョウバエ(モデル生物)
Research Abstract	WNK1 and WNK4 have been linked to a hereditary form of human hypertension known as Pseudohypoaldosteronism type II (PHAII). We identified that the malfunction of this regulation caused PHAII in mouse. However, this misregulation cannot cause all of pathological conditions of PHAII, such as a mental retardation, dental abnormalities and impaired growth. We started to look for the other interacting factor(s) of WNK using Drosophila melanogaster, and found the transcription factor, which worked at the downstream of WNK.