Joint disease and clock genes

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790250
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: Kanazawa University
• Principal Investigator: TAKARADA Takeshi Kanazawa University, 薬学系, 助教 (30377428)
• Project Period (FY): 2008 – 2009
• Keywords: 時計遺伝子 / 軟骨細胞 / 骨関節組織 / indian hedgehog

Research Abstract

We have investigated the possible role of clock genes in mechanism underlying the regulation of chondrogenic differentiation processes. The results suggested that chondrogenic differentiation may be modulated by clock genes expressed by chondrocytes in association with the inhibition by Per1 of Bmal1/Clock-dependent indian hedgehog expression.

Research Products

• [Journal Article] Induced tolerance to glutamate neurotoxicity through downregulation of NR2 subunits of N-methyl-D-aspartate receptors in cultured rat striatal neurons. (2010)
  • Author(s): Yuki Kambe, Noritaka Nakamichi, Takeshi Takarada, Ryo Fukumori, Yukio Yoneda
  • Journal Title: J. Neurosci. Res. (in press)
  • Peer Reviewed
• [Journal Article] Preferential inhibition by antidiarrheic 2-methoxy-4-methylphenol of Ca2+ influx across acquired N-methyl-D-aspartate receptor channels composed of NR1/NR2B subunit assembly. (2010)
  • Author(s): Noritaka Nakamichi*, Ryo Fukumori*, Takeshi Takarada, Yuki Kambe, Tomomi, Yamamoto, Nobuyuki Matsushima, Nobuaki Moriguchi, Yukio Yoneda
  • Journal Title: J. Neurosci. Res. (in press)
  • Peer Reviewed
• [Journal Article] Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate receptor channels. (2010)
  • Author(s): Ryo Fukumori*, Noritaka Nakamichi*, Takeshi Takarada, Yuki Kambe, Nobuyuki Matsushima, Nobuaki Moriguchi, Yukio Yoneda
  • Journal Title: J. Pharmacol. Sci. 112 Pages: 273-281
  • Peer Reviewed
• [Journal Article] A protein-protein interaction of stress-responsive myosin VI endowed to inhibit neural progenitor self-replication with RNA binding protein, TLS, in murine hippocampus. (2009)
  • Author(s): Takeshi Takarada*, Keisuke Tamaki*, Toru Takumi, Masato Ogura, Yuma Ito, Noritaka Nakamichi, Yukio Yoneda
  • Journal Title: J Neurochem 110 Pages: 1457-1468
  • Peer Reviewed
• [Journal Article] Interference by adrenaline with chondrogenic differentiation through suppression of gene transactivation mediated by Sox9 family members. (2009)
  • Author(s): Takeshi Takarada, Hironori Hojo, Mika Iemata, Koichi Sahara, Ayumi Kodama, Nobuhiro Nakamura, Eiichi Hinoi, Yukio Yoneda
  • Journal Title: Bone 45 Pages: 568-578
  • Peer Reviewed
• [Journal Article] Interference with cellular differentiation by D-serine through antagonism at N-methyl-D-aspartate receptors composed of NR1 and NR3A subunits in chondrocytes. (2009)
  • Author(s): Takeshi Takarada, Yoshifumi Takahata, Mika Iemata, Eiichi Hinoi, Kyosuke Uno, Takao Hirai, Tomomi Yamamoto, Yukio Yoneda
  • Journal Title: J Cell Physiol 220 Pages: 756-764
  • Peer Reviewed
• [Journal Article] Possible promotion of neuronal differentiation in fetal rat brain neural progenitor cells after sustained exposure to static magnetism. (2009)
  • Author(s): Noritaka Nakamichi, Yukichi Ishioka, Takao Hirai, Shusuke Ozawa, Masaki Tachibana, Nobuhiro Nakamura, Takeshi Takarada, Yukio Yoneda
  • Journal Title: J Neurosci Res 87 Pages: 2406-2417
  • Peer Reviewed
• [Journal Article] Predominant promotion by tacrolimus of chondrogenic differentiation to proliferating chondrocytes. (2009)
  • Author(s): Yukari Nakamura*, Takeshi Takarada*, Ayumi Kodama, Eiichi Hinoi, Yukio Yoneda
  • Journal Title: J Pharmacol Sci 109 Pages: 413-423
  • Peer Reviewed
• [Journal Article] Transactivation by runt related factor-2 of matrix metalloproteinase-13 in astrocytes. (2009)
  • Author(s): Takeshi Takarada, Yukio Yoneda
  • Journal Title: Neurosci Lett 451 Pages: 99-104
  • Peer Reviewed
• [Journal Article] Possible protection by notoginsenoside R1 against neurotoxicity of N-methyl-D-aspartate receptor composed of an NR1/NR2B heteromeric assembly. (2009)
  • Author(s): Bin Gu*, Noritaka Nakamichi*, Wen-Sheng Zhang, Yukary Nakamura, Yuki Kambe, Ryo Fukumori, Kazuhiro Takuma, Kiyofumi Yamada, Takeshi Takarada, Hideo Taniura, Yukio Yoneda
  • Journal Title: J Neurosci Res 87 Pages: 2145-2156
  • Peer Reviewed
• [Journal Article] Functional expression of beta2 adrenergic receptors responsible for protection against oxidative stress through promotion of glutathione synthesis after Nrf2 upregulation in undifferentiated mesenchymal C3H10T1/2 stem cells. (2008)
  • Author(s): Yoshifumi Takahata*, Takeshi Takarada*, Mika Iemata, Tomomi Yamamoto, Yukary Nakamura, Ayumi Kodama, Yukio Yoneda
  • Journal Title: J Cell Physiol 218 Pages: 268-275
  • Peer Reviewed
• [Journal Article] A critical importance of polyamine site in NMDA receptors for neurite outgrowth and fasciculation at early stages of P19 neuronal differentiation (2008)
  • Author(s): Danko D. Georgiev, Hideo Taniura, Yuki Kambe, Takeshi Takarada, Yukio Yoneda
  • Journal Title: Exp Cell Res 314 Pages: 2603-2617
  • Peer Reviewed
• [Journal Article] Differential regulation of cellular maturation in chondrocytes and osteoblasts by glycine. (2008)
  • Author(s): Yoshifumi Takahata, Takeshi Takarada*, Masato Osawa, Eiichi Hinoi, Yukari Nakamura, Yukio Yoneda
  • Journal Title: Cell Tissue Res 333 Pages: 91-103
  • Peer Reviewed
• [Presentation] 神経幹細胞とPTSD分子病態 (2010)
  • Author(s): 宝田剛志, 伊藤佑真, 米田幸雄
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 2010-06-17
• [Presentation] 脳虚血応答性遺伝子Ifrd1の機能解析 (2010)
  • Author(s): 宝田剛志, 小西志歩, 米田幸雄
  • Organizer: 第130回日本薬学会年会
  • Place of Presentation: 就実大学(岡山)
  • Year and Date: 2010-03-28
• [Presentation] アストロサイトに発現するRunx2の機能解析 (2010)
  • Author(s): 宝田剛志、米田幸雄
  • Organizer: 第24回放射性同位元素研究連絡会
  • Place of Presentation: 金沢大学(石川)
  • Year and Date: 2010-03-10
• [Presentation] Expressiom of Runt Related Factor-2 by Astrocytes (2009)
  • Author(s): Takeshi Takarada, Mika Takarada, Masaki Tachibana, Yukio Yoneda
  • Organizer: 第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学会合同年会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 20091113-20091115
• [Presentation] Clock Genes Expressed by Microglial Cells. (2009)
  • Author(s): Tomomi Yamamoto, Takeshi Takarada, Ayumi Kodama, Masaki Tachibana, Yukio Yoneda
  • Organizer: 第19回日本臨床精神神経薬理学会・第39回日本神経精神薬理学会合同年会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 20091113-20091115
• [Presentation] Bone-related genes expressed in brain. (2009)
  • Author(s): Takeshi Takarada, Yukio Yoneda
  • Organizer: The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
  • Place of Presentation: BEXCO(Korea)
  • Year and Date: 20090823-20090828
• [Presentation] Clock genes expressed in cultured microglia. (2009)
  • Author(s): Yamamoto, T., Takarada, T., Kodama, A., Tachibana, M., Yoneda, Y.
  • Organizer: The 22nd Biennial Meeting of the ISN/APSN Joint Meeting
  • Place of Presentation: BEXCO(Korea)
  • Year and Date: 20090823-20090828
• [Presentation] アストロサイトにおけるRunt related factor-2の機能的発現 (2009)
  • Author(s): 宝田剛志, 家亦美佳, 橘正毅, 米田幸雄
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 伊香保温泉ホテル天坊(群馬)
  • Year and Date: 20090621-20090624
• [Presentation] ミクログリア細胞における時計遺伝子の機能的発現 (2009)
  • Author(s): 山本朋未, 宝田剛志, 米田幸雄
  • Organizer: 第52回日本神経化学会大会
  • Place of Presentation: 伊香保温泉ホテル天坊(群馬)
  • Year and Date: 20090621-20090624
• [Presentation] 時計遺伝子Per1による軟骨細胞成熟調節 (2009)
  • Author(s): テル天坊(群馬) [11]児玉歩美, 宝田剛志, 佐原甲一, 檜井 栄一, 米田幸雄
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 20090326-20090328
• [Presentation] 時計遺伝子による軟骨細胞成熟過程の制御 (2009)
  • Author(s): 児玉歩美, 宝田剛志, 檜井栄一, 米田 幸雄
  • Organizer: 第116回日本薬理学会近畿部会
  • Place of Presentation: ピアザ淡海(滋賀)
  • Year and Date: 2009-11-13
• [Presentation] 軟骨細胞に発現するIndian hedgehogの時計遺伝子による調節機構 (2008)
  • Author(s): 宝田剛志, 佐原甲一, 米田幸雄
  • Organizer: 第26回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪)
  • Year and Date: 20081029-20081031
• [Presentation] ミクログリア細胞に発現する時計遺伝子 (2008)
  • Author(s): 山本朋未, 宝田剛志, 佐原甲一, 小椋 正人, 谷浦秀夫, 米田幸雄
  • Organizer: 第18回日本臨床精神神経薬理学会・第38回日本神経精神薬理学会合同年会
  • Place of Presentation: 品川プリンスホテル(東京)
  • Year and Date: 20081001-20081003
• [Presentation] ミクログリア細胞に発現する時計遺伝子群 (2008)
  • Author(s): 山本朋未, 宝田剛志, 佐原甲一, 橘正毅, 谷浦秀夫, 米田幸雄
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 第51回日本神経化学会大会(富山)
  • Year and Date: 20080911-20080913
• [Presentation] 軟骨細胞分化における時計遺伝子Period1の役割 (2008)
  • Author(s): 児玉歩美, 佐原甲一, 宝田剛志, 米田 幸雄
  • Organizer: 生体機能と創薬シンポジウム
  • Place of Presentation: 星薬科大学(東京)
  • Year and Date: 20080905-20080906
• [Presentation] 時計遺伝子による軟骨細胞株ATDC5細胞の分化制御 (2008)
  • Author(s): 佐原甲一, 宝田剛志, 檜井栄一, 米田 幸雄
  • Organizer: 第113回日本薬理学会近畿部会
  • Place of Presentation: ホテルグランヴィア岡山(岡山)
  • Year and Date: 2008-06-20
• [Presentation] ミクログリア細胞における時計遺伝子の発現 (2008)
  • Author(s): テルグランヴィア岡山(岡山) [17]山本朋未, 宝田剛志, 佐原甲一, 小椋 正人, 谷浦秀夫, 米田幸雄
  • Organizer: 第113回日本薬理学会近畿部会
  • Place of Presentation: ホテルグランヴィア岡山(岡山)
  • Year and Date: 2008-06-20