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2009 Fiscal Year Final Research Report

Analysis of plasticity of cancer cell motility in 3D substrates

Research Project

  • PDF
Project/Area Number 20790254
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionKobe University

Principal Investigator

YAMAZAKI Daisuke  Kobe University, 大学院・医学研究科, 助教 (50422415)

Project Period (FY) 2008 – 2009
Keywords癌 / シグナル伝達
Research Abstract

The motility of cancer cells in 3D matrices is of two types : mesenchymal motility, in which the cells are elongated and amoeboid motility, in which the cells are round. Amoeboid motility is driven by an actomyosin-based contractile force, which is regulated by the Rho/ROCK pathway. Here I show that the motility of elongated cells is regulated by Rac signaling through formation of elongated pseudopodia and cell-substrate adhesion.

  • Research Products

    (4 results)

All 2009 2008

All Journal Article (1 results) Presentation (3 results)

  • [Journal Article] Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates2009

    • Author(s)
      山崎大輔、栗栖修作、竹縄忠臣
    • Journal Title

      Oncogene誌 28巻

      Pages: 1570-1583

  • [Presentation] Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates2009

    • Author(s)
      山崎大輔
    • Organizer
      第61回日本細胞生物学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2009-06-04
  • [Presentation] Regulation of actin reorganization by WAVE family proteins during morphogenesis2008

    • Author(s)
      山崎大輔
    • Organizer
      第31回日本分子生物学会年会、第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2008-12-09
  • [Presentation] がん細胞におけるアクチン細胞骨格制御因子の役割2008

    • Author(s)
      山崎大輔
    • Organizer
      第60回日本細胞生物学会
    • Year and Date
      2008-06-30

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Published: 2011-06-18   Modified: 2016-04-21  

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