2009 Fiscal Year Final Research Report
Role of the membrane-anchored growth factor in the cell cycle regulation of cancer stem cells
| Project/Area Number |
20790259
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Ehime University |
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Principal Investigator |
FUKUDA Shinji Ehime University, 大学院・医学系研究科, 助教 (70398238)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 分子腫瘍学 / 膜型増殖因子 |
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| Research Abstract |
Recent studies suggests that tumors arise from cancer stem cells. Here, we focused on a membrane-anchored growth factor, Amphiregulin (AREG), which is thought to be expressed in side-population (SP) of hepatocyte cell line, Huh7. We identified AREG-regulating protein (ARP), whose expression is also detected in Huh7 SP. ARP promotes the production of soluble AREG (N-terminal fragment of AREG), thus might be involved in the cell cycle regulation of hepatocyte stem cell regulation.
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