2010 Fiscal Year Final Research Report
Analysis of the functions of the PAR-aPKC complex in the regulation of the slit diaphragm proteins
Project/Area Number |
20790261
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Pathological medical chemistry
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Research Institution | Yokohama City University |
Principal Investigator |
HIROSE Tomonori Yokohama City University, 医学部, 助教 (20381668)
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Project Period (FY) |
2008 – 2010
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Keywords | シグナル伝達 / 疾患モデル動物 / 糸球体疾患 / 細胞極性 / 腎臓病 |
Research Abstract |
The prevalence of end-stage renal disease (ESRD) in Japan have reached more than 290,000 by the end of 2009 and is still increasing by 10,000 a year. Although glomerular diseases cause about 80% of ESRD, the mechanisms of the pathophysiology and progression of glomerular diseases are still obscure. To resolve this situation, I established a new mouse line with a glomerular disease based on the disturbance in podocyte cell polarity and revealed a new aspect of the molecular mechanisms to maintain glomerular filtration function. These results would contribute to our understanding of the molecular pathophysiology of glomerular diseases and to the innovation of diagnostic techniques or medical interventions.
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[Journal Article] Intrarenal suppression of angiotensin II type 1 receptor binding molecule in angiotensin II-infused mice.2010
Author(s)
Wakui H, Tamura K, Matsuda M, Bai Y, Dejima T, Shigenaga AI, Masuda S, Azuma K, Maeda A, Hirose T, Ishigami T, Toya Y, Yabana M, Minamisawa S, Umemura S.
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Journal Title
Am J Physiol Renal Physiol. 299(5)
Pages: F991-1003
Peer Reviewed
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[Journal Article] Expression of angiotensin II type 1 receptor-interacting molecule in normal human kidney and IgA nephropathy.2010
Author(s)
Masuda S, Tamura K, Wakui H, Maeda A, Dejima T, Hirose T, Toyoda M, Azuma K, Ohsawa M, Kanaoka T, Yanagi M, Yoshida S, Mitsuhashi H, Matsuda M, Ishigami T, Toya Y, Suzuki D, Nagashima Y, Umemura S.
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Journal Title
Am J Physiol Renal Physiol. 299(4)
Pages: F720-731
Peer Reviewed
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[Journal Article] Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis.2010
Author(s)
Machida H, Ito S, Hirose T, Takeshita F, Oshiro H, Nakamura T, Mori M, Inayama Y, Yan K, Kobayashi N, Yokota S.
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Journal Title
Nephrol Dial Transplant. 25(8)
Pages: 2530-2537
Peer Reviewed
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[Journal Article] An essential role of the universal polarity protein, aPKClambda, on the maintenance of podocyte slit diaphragms.2009
Author(s)
Hirose T, Satoh D, Kurihara H, Kusaka C, Hirose H, Akimoto K, Matsusaka T, Ichikawa I, Noda T, Ohno S.
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Journal Title
PLoS ONE. 4(1)
Pages: e4194
Peer Reviewed
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[Remarks] McCarthy, N., Research Highlight.Cell Polarity : ASPP2 gets a polarity complex.Nat Rev Cancer, 10:528.(August 2010)
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[Remarks] Holzman, B.H., Garg P., In This issue.Initial Insight on the Determinants of Podocyte Polarity.J Am Soc Nephrol, 20: 683-685.(April 2009)
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[Remarks] 読売新聞 平成21年2月22日
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[Remarks] 科学新聞 平成21年1月23日
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