2009 Fiscal Year Final Research Report

The isolation of atopy dermatitis association genes based on transepidermal water loss and gene polymorphism of skin barrier association genes

Research Project

Project/Area Number	20790268
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Human genetics
Research Institution	Keio University
Principal Investigator	SASAKI Takashi Keio University, 総合研究機構, 講師 (70306843)
Project Period (FY)	2008 – 2009
Keywords	遺伝子診断学 / アトピー性皮膚炎 / フィラグリン / 経皮水分蒸散量
Research Abstract	In this study, I determined the DNA sequence of skin barrier associated genes (LEP7, hKPRP, LCE1F, SPRR2E) derived from atopy dermatitis patients. As a result, I did not find critical mutations which would cause dysfunction of skin barrier in these genes, however, I decided the frequency of polymorphism of these genes in atopy dermatitis patients. I expect that the comparison these polymorphisms of these gens between atopy dermatitis patients and controls would be clear the relationships among these genes and atopy dermatitis.