2009 Fiscal Year Final Research Report

LKB-1, K-ras, and EGFR gene mutation involvement in the multistep tumorigenesis of primary lung adenocarcinomas

Research Project

Project/Area Number	20790274
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Human pathology
Research Institution	Chiba University
Principal Investigator	OIDE Takashi Chiba University, 大学院・医学研究院, 助教 (00422246)
Project Period (FY)	2008 – 2009
Keywords	病理学 / 肺癌 / 腺癌 / 発癌
Research Abstract	In the present study, we detected a case of primary pulmonary adenocarcinoma with an immunohistochemically proven ALK abnormality. The tumor showed an endobronchial polypoid growth pattern with peripheral pulmonary tissue invasion. Recently, lung cancers having ALK gene abnormalities have attracted growing attention because of therapeutic aspects, i.e., ALK inhibitor therapies. The present case is the first case of ALK-immunopositive lung cancer suggesting central bronchial surface epithelial origin.