2009 Fiscal Year Final Research Report
Elucidation of epithelial-stromal interactions in prostate cancer using global gene expression analysis
| Project/Area Number |
20790275
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MORIKAWA Teppei The University of Tokyo, 医学部附属病院, 助教 (80451772)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 前立腺癌 / 間質 / ペリオスチン / 組織マイクロアレイ |
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| Research Abstract |
We focused on periostin, which was specifically expressed by prostate cancer stromal cells. We examined the expression of periostin protein in surgically resected prostate cancers by immunohistochemistry using a tissue microarray. We confirmed that periostin was exclusively expressed by prostate cancer stromal cells, but not by normal or cancerous epithelial cells. There was no significant association between periostin expression and clinicopathological features. Periostin expression in the stroma of prostate cancer may be a potential diagnostic marker.
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[Journal Article] Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma2009
Author(s)
Hino R, Uozaki H, Murakami N, Ushiku T, Shinozaki A, Ishikawa S, Morikawa T, Nakaya T, Sakatani T, Takada K, Fukayama M
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Journal Title
Cancer Res 69(7)
Pages: 2766-74
Peer Reviewed
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