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2009 Fiscal Year Final Research Report

The role of a small cell lung cancer -specific alternative splice variant of TSLC1 in metastasis.

Research Project

  • PDF
Project/Area Number 20790276
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionThe University of Tokyo

Principal Investigator

IWAI Miwako  The University of Tokyo, 医科学研究所, 技術専門職員 (50396884)

Project Period (FY) 2008 – 2009
Keywords分子病理 / 小細胞肺癌 / 細胞接着分子 / TSLC1 / CADM1 / スプライシングバリアント
Research Abstract

Small cell lung cancer (SCLC) accounts for about 20% of lung cancer in Japan. Although chemotherapy is initially effective to SCLC, SCLC often becomes resistant to any therapeutic approaches. Molecular targeting therapy, however, has not been established so far against SCLC. In this study, we found that a cell adhesion molecule, TSLC1/CADM1, was frequently overexpressed in cancer cells and primary tumors from SCLC, and showed a specific splicing isoform which was not observed in normal lung or brain. Furthermore, the exogenous expression of this variant TSLC1 promoted the tumorigenicity of SCLC cells in nude mice. These findings suggested that this splicing variant was associated with the malignant growth and metastasis of SCLC and could provide a useful marker for the diagnosis of SCLC.

  • Research Products

    (8 results)

All 2011 2010 2009 2008

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results)

  • [Journal Article] Transcriptional regulation of the CADM1 gene by retinoic acid during the neural differentiation of murine embryonal carcinoma P19 cells.2011

    • Author(s)
      Ito T, Williams-Nate Y, Iwai M, Tsuboi Y, Hagiyama M, Ito A, Sakurai-Yageta M, Murakami Y.
    • Journal Title

      Genes to Cells 掲載確定

    • Peer Reviewed
  • [Journal Article] Aberrant expression of tumor suppressors CADM1 and 4.1B in invasive lesions of primary breast cancer.2011

    • Author(s)
      Takahashi Y, Iwai M, Kawai T, Arakawa A, Ito T, Sakurai-Yageta M, Ito A, Goto A, Saito M, Kasumi F, Murakami Y.
    • Journal Title

      Breast Cancer [Epub ahead of print]

    • Peer Reviewed
  • [Journal Article] 頭頸部癌におけるTP53・EGFR遺伝子異常の解析2011

    • Author(s)
      蝦原康宏、岩井美和子、吉田昌史、安藤瑞生、朝蔭孝宏、山岨達也、村上善則
    • Journal Title

      頭頸部癌 37(1)

      Pages: 1-6

    • Peer Reviewed
  • [Presentation] Involvement of a cell adhesion molecule CADM1/TSLC1 in oncogenesis2010

    • Author(s)
      村上善則
    • Organizer
      The 15th Charles Heidelberger International Symposium on Cancer Research
    • Place of Presentation
      タイ国、ピサヌロック市
    • Year and Date
      20100118-20100120
  • [Presentation] 細胞接着分子CADM1の小細胞肺癌における特異的スプライシングバリアントの同定2010

    • Author(s)
      菊池慎二
    • Organizer
      第51回日本肺癌学会総会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2010-11-04
  • [Presentation] Involvement of a cell adhesion molecule CADM1/TSLC1 in oncogenesis2009

    • Author(s)
      村上善則
    • Place of Presentation
      台湾、台北市
    • Year and Date
      20091209-20091210
  • [Presentation] 細胞接着分子CADM1/TSLC1の異常による肺腫瘍形成の分子機構2008

    • Author(s)
      村上善則
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-30
  • [Presentation] がん抑制遺伝子CADM1/TSLC1による肺がん抑制機構の解析2008

    • Author(s)
      村上善則
    • Organizer
      第23回日本肺癌学会ワークショップ
    • Place of Presentation
      愛知県がんセンター
    • Year and Date
      2008-07-19

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Published: 2012-02-13   Modified: 2016-04-21  

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