The role of allograft aging and senescence in allograft dysfunction after liver transplantation

2010 Fiscal Year Final Research Report

• Project/Area Number: 20790282
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Human pathology
• Research Institution: Kyoto University
• Principal Investigator: MIYAGAWA Aya Kyoto University, 医学研究科, 講師 (90432385)
• Project Period (FY): 2008 – 2010
• Keywords: 移植病理 / 肝グラフト / 老化

Research Abstract

This is the first study to compare stable human liver allografts versus chronically rejected allografts in the long-term after liver transplantation from the viewpoint of genomic instability, specially telomere shortening, chimerism, and aneuploidy. The telomere decline at 10 years post-transplant, the telomere decline rate at the first year after transplantation, and hepatocellular aneuploidy at 10 years post-transplant were seen greater in rejection group than those of stable group, although advanced aneuploidy and telomere shortening for the presumed allograft age was seen in both groups.

Research Products

• [Journal Article] Liver transplantation for severe hepatitis in patients with common variable immunodeficiency. (2011)
  • Author(s): Murakawa Y, Miyagawa-Hayashino A, et al.
  • Journal Title: Pediatric Transpl in press
  • Peer Reviewed
• [Journal Article] Frequent overlap of active hepatitis in recurrent primary sclerosing cholangitis after living donor liver transplantation related to its rapidly progressive course. (2011)
  • Author(s): Miyagawa-Hayashino A, Egawa H, Yoshizawa A, Ueda Y, Ichida T, Ueno Y, Uemoto S, Harada K, Nakanuma Y.
  • Journal Title: Hum Pathol
  • Peer Reviewed
• [Journal Article] Effect of maintenance therapy with low-dose peginterferon for recurrent hepatitis C after living donor liver transplantation. (2010)
  • Author(s): Ueda Y, Marusawa H, Kaido T, Ogura Y, Oike F, Mori A, Ogawa K, Yoshizawa A, Hatano E, Miyagawa-Hayashino A, et al.
  • Journal Title: J Viral Hepat
  • Peer Reviewed
• [Journal Article] Does a positive lymphocyte cross-match contraindicate living-donor liver transplantation? (2010)
  • Author(s): Hori T, Uemoto S, Takada Y, Oike F, Ogura Y, Ogawa K, Miyagawa-Hayashino A, et al.
  • Journal Title: Surgery 147 Pages: 840-844
  • Peer Reviewed
• [Journal Article] Hepatic venous outflow obstruction in pediatric living donor liver transplantation using left-sided lobe grafts : Kyoto university experience. (2010)
  • Author(s): Sakamoto S, Egawa H, Kanazawa H, Shibata T, Miyagawa-Hayashino A, et al.
  • Journal Title: Liver Transpl 16 Pages: 1207-1214
  • Peer Reviewed
• [Journal Article] Living-donor Liver Transplantation for Progressive Familial Intrahepatic Cholestasis. (2010)
  • Author(s): Hori T, Egawa H, Miyagawa-Hayashino A, Yorifuji T, Yonekawa Y, Nguyen JH, Uemoto S.
  • Journal Title: World J Surg
  • Peer Reviewed
• [Journal Article] Progressive familial intrahepatic cholestasis : a single-center experience of living-donor liver transplantation during two decades in Japan. (2010)
  • Author(s): Hori T, Egawa H, Takada Y, Ueda M, Oike F, Ogura Y, Sakamoto S, Kasahara M, Ogawa K, Miyagawa-Hayashino A, et al.
  • Journal Title: Clin Transplant
  • Peer Reviewed
• [Journal Article] Non-specific interstitial pneumonia as a manifestation of graft-versus-host disease following pediatric allogeneic hematopoietic stem cell transplantation (2010)
  • Author(s): Miyagawa-Hayashino A, Sonobe M, Kubo T, Yoshizawa A, Date H, Manabe T.
  • Journal Title: Pathol Int 60 Pages: 137-142
  • Peer Reviewed
• [Journal Article] Allograft steatohepatitis in progressive familial intrahepatic cholestasis, type 1, after living donor liver transplantation (2009)
  • Author(s): Miyagawa-Hayashino A, Egawa H, Yorifuji T, Hasegawa M, Haga H, Tsuruyama T, Wen M-C, Sumazaki R, Manabe T, Uemoto S.
  • Journal Title: Liver Transpl 15 Pages: 610-618
  • Peer Reviewed
• [Journal Article] Idiopathic post-transplantation hepatitis following living donor liver transplantation, and significance of autoantibody titre for outcome. (2009)
  • Author(s): Miyagawa-Hayashino A, Haga H, Egawa H, Hayashino Y, Uemoto S, Manabe T.
  • Journal Title: Transpl Int 22 Pages: 303-312
  • Peer Reviewed
• [Journal Article] 上本伸二肝移植後の自己免疫性肝炎の再発とde novo自己免疫性肝炎 (2009)
  • Author(s): 宮川文、江川裕人
  • Journal Title: 肝胆膵 59 Pages: 101-107
• [Journal Article] 真鍋俊明肝液性拒絶反応の病理所見 (2008)
  • Author(s): 宮川文、江川裕人、上本伸二
  • Journal Title: 移植 43 Pages: 194-198
• [Journal Article] 真鍋俊明生体肝移植後晩期合併症の病理 (2008)
  • Author(s): 羽賀博典、宮川文
  • Journal Title: 病理と臨床 26 Pages: 40-47
• [Presentation] 羽賀博典肝移植後長期経過例の肝細胞の老化の検討 (2011)
  • Author(s): 宮川文、鶴山竜昭、ウラムジャン・アイニ、橋本誠司
  • Organizer: 第100回日本病理学会総
  • Place of Presentation: 横浜 一般口演
  • Year and Date: 2011-04-30
• [Presentation] 肝移植における胆管病変 (2011)
  • Author(s): 羽賀博典、鶴山竜昭、宮川文
  • Organizer: 第100回日本病理学会総会 ワークショップ11 胆管系の病理:最近の展開
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-30
• [Presentation] 肝移植後のde novo AIH (2010)
  • Author(s): 宮川文
  • Organizer: 第18回日本消化器関連学会期間JDDW 2010第14回日本肝臓学会特別企画 肝臓病理一日コース
  • Place of Presentation: 横浜 招待講演
  • Year and Date: 2010-10-14
• [Presentation] 成人生体肝移植後の慢性拒絶反応発症の背景について (2010)
  • Author(s): 宮川文, 以下9人
  • Organizer: 第28回日本肝移植研究会 シンポジウム5慢性拒絶反応の克服
  • Place of Presentation: 広島
  • Year and Date: 2010-07-02
• [Presentation] 真鍋俊明分類不能型免疫不全症を背景に劇症肝炎により肝移植に至った2例 (2010)
  • Author(s): 宮川文、黒澤学、村川泰裕
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京 一般ポスター
  • Year and Date: 2010-04-28
• [Presentation] 真鍋俊明Down症候群に伴った乳児肝障害の一例第27 回日本肝移植研究会 (2009)
  • Author(s): 大月聡明、宮川文、吉澤明彦、岡本晋弥、上本伸二
  • Organizer: 第11回肝移植病理検討会
  • Place of Presentation: 三島
  • Year and Date: 2009-07-11
• [Presentation] 真鍋俊明小児生体肝移植におけるQuantitative FISH法を用いた肝細胞テロメア長の評価 (2009)
  • Author(s): Aini Wulamjiang、宮川(林野)文、鶴山竜昭
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京都 一般口演
  • Year and Date: 2009-05-03
• [Presentation] 肝移植の病理 (2008)
  • Author(s): 宮川文
  • Organizer: 第43回日本病理学会近畿支部学術集会病理講習会テーマ"肝の炎症性疾患"
  • Place of Presentation: 大阪 講演
  • Year and Date: 2008-12-06
• [Book] Histopathology in living-donor liver transplantation.(Chapter 12)(Tanaka K, Inomata Y, Uemoto S, Kiuchi T ed.)(Evolution of living-donor liver transplantation.)(Barcelona, Spain) (2008)
  • Author(s): Haga H, Tsuruyama T, Miyagawa-Hayashino A.
  • Total Pages: 313-330
  • Publisher: Thomson reuters