2009 Fiscal Year Final Research Report
Genomic profiling of gastric carcinoma in situ by array-based comparative genomic hybridization
| Project/Area Number |
20790286
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2009
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| Keywords | 分子病理 / アレイCGH |
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| Research Abstract |
Although genomic copy number aberrations (CNAs) of gastric carcinoma at the advanced stage have already been extensively characterized by array comparative genomic hybridization (array CGH) analysis, those of gastric carcinoma in situ (CIS) are still poorly understood. In this study, we investigated CNAs of 20 gastric CISs (Vienna category 4.2) using oligonucleotide-based array CGH. The most frequent aberrations in CIS were gains at 8q (85%) and 20q (50%), and losses at 5q (50%) and 17p (50%), suggesting that these CNAs are involved in the development of CIS.
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