2009 Fiscal Year Final Research Report
Functional analysis of a new Trem molecule
Project/Area Number |
20790299
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Experimental pathology
|
Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
HEMMI Hiroaki Tokyo Medical and Dental University, 難治疾患研究所, 特任講師 (20451924)
|
Project Period (FY) |
2008 – 2009
|
Keywords | 分子 / 樹状細胞 / マクロファージ / サイトカイン産生 |
Research Abstract |
Triggering receptor expressed on myeloid cells (Trem) family is known to regulate activation status of immune cells. In this study, we tried to uncover the function of a newly identified Trem molecule. It has been reported that the expression levels of other Trem members are up-regulated or down-regulated when the cells were activated. However, the expression of this molecule on dendritic cells (DCs) was not altered after their activation. In addition, the results from analyses of gene-knocked out mice suggest that this molecule is not involved in uptake of apoptotic cells by DCs. On the other hand, gene knocked-out mice showed slightly enhanced responses in terms of cytokine productions and antibody induced arthritis, suggesting that this molecule may be negatively involved in inflammatory responses.
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Research Products
(4 results)