2009 Fiscal Year Final Research Report
)Exploratory analysis for functional genes which regulate the malignant features of glioblastoma
| Project/Area Number |
20790307
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
FUKUSHIMA Tsuyoshi University of Miyazaki, 医学部, 助教 (10452913)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 遺伝子 / 癌 / 細胞・組織 / 病理学 / 脳神経疾患 |
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| Research Abstract |
Glioblastoma is the most malignant brain tumor with very poor prognosis. I aimed to identify novel functional genes influencing the malignant features of glioblastoma by analyzing some genes overexpressed by glioblastomas whose detailed functions remain unknown. In this study, I focused on IGFBP-2 and CD24, both of which were involved in the invasive growth of glioblastoma. The cDNA microarrays for transcriptional profiling revealed significantly reduced expression of progression-associated genes and enhanced expression of suppression-associated genes in response to IGFBP-2 or CD24 knockdown in glioblastoma cell lines. Furthermore, about 30 functional genes were identified as candidates for positive regulators of IGFBP-2 by an expression cloning method. These genes and the related signal transductions serve as potential therapeutic targets in glioblastoma.
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