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2009 Fiscal Year Final Research Report

Generation of a medaka model for in vivo analysis of tumor cells

Research Project

  • PDF
Project/Area Number 20790313
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

HASEGAWA Sumitaka  National Institute of Radiological Sciences, 分子イメージング研究センター, 主任研究員 (60415437)

Project Period (FY) 2008 – 2009
Keywords疾患モデル動物
Research Abstract

We generated a medaka model capable of allowing the observation of various cell behaviors of transplanted tumors cells, such as cell proliferation and metastasis, which were visualized easily in vivo. Medaka melanoma cells stably expressing green fluorescence protein were established and transplanted into medaka with same genetic background. We could easily visualize tumor growth and metastasis of the transplanted cells at a single level resolution in vivo. Our medaka model provides an opportunity to visualize in vivo tumor cells "as seen in a culture dish" and would be useful for in vivo tumor cell biology.

  • Research Products

    (3 results)

All 2009 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] A medaka model of cancer allowing direct observation of transplanted tumor cells in vivo at a cellular-level resolution2009

    • Author(s)
      Sumitaka Hasegawa, Kouichi Maruyama, Hikaru Takenaka, Takako Furukawa, Tsuneo Saga
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America Vol.106

      Pages: 13832-13837

    • Peer Reviewed
  • [Presentation] メダカがんモデル:生体内がん細胞動態の直接観察2009

    • Author(s)
      長谷川純崇、古川高子、佐賀恒夫
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-10-03
  • [Remarks] 毎日新聞全国版夕刊(2009年8月5日)記事掲載

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Published: 2011-06-18   Modified: 2016-04-21  

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