2009 Fiscal Year Final Research Report
Clinical and basic analysis of biosynthetic genes for staphylococcal signaling substances for virulence
| Project/Area Number |
20790332
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Nagoya University |
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Principal Investigator |
KEIKO Yamada Nagoya University, 大学院・医学系研究科, 助教 (00402561)
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| Project Period (FY) |
2008 – 2009
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| Keywords | セカンドメッセンジャー / 情報伝達シグナル物質 / cyclic-di-GMP / cyclic-di-AMP / バイオフィルム / カテーテル感染 / ブドウ球菌 |
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| Research Abstract |
Cyclic-di-GMP affected suppressively on biofilm formation. A biosynthetic gene of cyclic-di-AMP became identified and was confirmed its function. It is essential in Staphylococcus aureus. Internal concentration of cyclic-di-GMP and cyclic-di-AMP did not affected by plasmid-mediated overexpression, presumed the strict regulation system on the production of these molecules. Amount of biofilm formation of clinical isolates associated with catheter infection varied among strains and not related with their origins. Biofilm of some strains were affected by DNase, Proteinase K or Dispersin B indicated that components of biofilm also differ among strains.
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[Journal Article] Detection of invasive protein profile of Streptococcus pyogenes M1 isolates from pharyngitis patients.2010
Author(s)
Hasegawa, T., A. Okamoto, T. Kamimura, I. Tatsuno, S.N. Hashikawa, M. Yabutani, M. Matsumoto, K. Yamada, M. Isaka, M. Minami, M. Ohta.
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Journal Title
Peer Reviewed
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