2009 Fiscal Year Final Research Report
Molecular mechanisms of intracellular survival of M. tuberculosis inside host macrophages via regulation of caspases activation.
| Project/Area Number |
20790334
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Hyogo College of Medicine |
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Principal Investigator |
UCHIYAMA Ryosuke Hyogo College of Medicine, 医学部, 助教 (20456891)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 結核菌 / マクロファージ / カスパーゼ / IL-18 / FasL / Fasシグナル |
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| Research Abstract |
On the basis of regulation of caspase(s) in host macrophages infected with M. tuberculosis (MTB) and the typical intracellular bacteria L. monocytogenes (LM), we have shown that caspase-1 activation was induced in macrophages infected with MTB, which leads to the production of functional inflammatory cytokines IL-1β and IL-18. We also found that the virulence factor RD1 of MTB involved in the activation of caspase-1 in macrophages. FasL/Fas signaling pathway is an important systems for caspase(s) activation. We have unveiled the involvement of Fas signaling pathway for IL-18 production in mice infected with BCG or LM.
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