2010 Fiscal Year Final Research Report
Functional analysis of Toll-like receptor 10
| Project/Area Number |
20790342
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kurume University |
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Principal Investigator |
SHIMIZU Takashi Kurume University, 医学部, 助教 (40320155)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 感染免疫 |
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| Research Abstract |
TLR10 expression in 293T cells suppressed the activation of NF-κB by lipoproteins through TLR2. This result indicates that TLR10 plays an important role to inhibit and control the inflammatory responses induced by TLR2.
We examined the relationship between TLR10 and TLR2 independent inflammatory responses induced by cytoadherence of Mycoplasma pneumoniae. The induction of TLR2 independent inflammatory responses by cytoadherence of M. pneumonia was dependent of ATP and P2X7 receptor, but independent of TLR10.
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