2011 Fiscal Year Final Research Report
Elucidation of function of increasing toxin in the streptococcal toxic shock syndrome clinical isolates and of the regulation
| Project/Area Number |
20790345
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
IKEBE Tadayoshi 国立感染症研究所, 細菌第一部, 主任研究官 (20333362)
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| Project Period (FY) |
2008 – 2011
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| Keywords | 病原性 |
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| Research Abstract |
Streptococcal toxic shock syndrome(STSS) is a severe invasive infection characterized by the sudden onset of shock and multiorgan failure ; it has a high mortality rate. In the present study, mutations of another negative regulator, rgg, were also found in clinical isolates of STSS patients. The rgg mutants from STSS clinical isolates enhanced lethality and impaired various organs in the mouse models and precluded their being killed by human neutrophils. When we assessed the mutation frequency of rgg gene among S. pyogenes isolates from STSS and non-invasive infections, about 25% of the STSS isolates had mutations of rgg gene, while isolates from patients with non-invasive disease had significantly fewer mutations in this gene(1.7%). The results of the present study suggest that mutations in the negative regulators csrS/csrR and rgg of S. pyogenes are crucial factors in the pathogenesis of STSS, as they lead to the overproduction of multiple virulence factors.
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[Journal Article] The Working Group forβ-hemolytic Streptococci in Japan. Emergence of clindamycin-resistant Streptococcus pyogenes isolates obtained from patients with severe invasive infections in Japan2010
Author(s)
Ikebe T, Wada A, Oguro Y, Ogata K, Katsukawa C, Isobe J, Shima T, Suzuki R, Ohya H, Tominaga K, Okuno R, Uchitani Y, Watanabe H
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Journal Title
Jpn J Infect Dis
Volume: 63
Pages: 304-305
Peer Reviewed
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[Journal Article] The Working Group forβ-hemolytic Streptococci in Japan. Surveillance of severe invasive group G streptococcal infections during 2002-2008 in Japan2010
Author(s)
Ikebe T, Oguro Y, Ogata K, Katsukawa C, Isobe J, Shima T, Suzuki R, Ohya H, Tominaga K, Okuno R, Uchitani Y, Tada Y, Okabe N, Watanabe H
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Journal Title
Jpn J Infect Dis
Volume: 63
Pages: 372-375
Peer Reviewed
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[Journal Article] Invasive group A streptococcal infection in pregnancy2010
Author(s)
Yamada T, Yamada T, Yamamura MK, Katabami K, Hayakawa M, Tomaru U, Shimada S, Morikawa M, Seki T, Ariga S, Ishikawa K, Ikebe T, Gando S, Minakami H
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Journal Title
J Infect
Volume: 60
Pages: 417-424
Peer Reviewed
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[Journal Article] Working Group for Beta-Haemolytic Streptococci in Japan. T serotyping of Streptococcus pyogenes in Aichi Prefecture, Japan isolated between 2003 and 20072009
Author(s)
Matsumoto M, Yamaguchi I, Sasano M, Hori M, Ikezaki K, Shimizu S, Nishiyama Y, Sato N, Tsuchiya H, Suzuki M, Minagawa H
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Journal Title
Jpn J Infect Dis
Volume: 62
Pages: 168-169
Peer Reviewed
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[Journal Article] Genetic features of clinical isolates of Streptococcus dysgalactiae subsp. equisimilis possessing Lancefield's group A antigen2008
Author(s)
Tanaka, D., Isobe, J., Watahiki, M., Nagai, Y., Katsukawa, C., Kawahara, R., Endoh, M., Okuno, R., Kumagai, N., Matsumoto, M., Morikawa, Y., Ikebe, T., Watanabe, H., and the Working Group for Group A Streptococci in Japan
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Journal Title
J. Clin. Microbiol
Volume: 46
Pages: 1526-1529
Peer Reviewed
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[Presentation] Molecular Epidemiology of group A Streptococcus isolated from patients with severe invasive infections in Japan during 2004-20102011
Author(s)
Ikebe T, Katsukawa C, Ohya H, Suzuki R, Oguro Y, Tominaga K, Shima T, Isobe J, Ogata K, Okuno R, Fujimoto T, Tada Y, Okabe N, Ohnishi M, Watanabe H, The Working Group forβ-hemolytic Streptococci in Japan
Organizer
XVIII Lancefield International Symposium
Place of Presentation
Italy, Palermo
Year and Date
20110904-08
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