2009 Fiscal Year Final Research Report
Extensive analysis of human cellular factors that target simian immunodeficiency virus replication
| Project/Area Number |
20790350
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
TAKEUCHI Hiroaki The University of Tokyo, 医科学研究所, 特任助教 (20451867)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Keywords | 感染防御 / ワクチン |
|---|
| Research Abstract |
An understanding of host cell factors that affect viral replication contributes to elucidation of the mechanism for determination of viral tropism. SIV infection was not significantly affected by knock-down of CypA, an essential factor for HIV-1 replication, but enhanced by knock-down of CypB, another PPIase, in human target cells. These results imply different effects of CypA/CypB on HIV-1 and SIV replication.
|
