The roles of osteopontin and IL-17 in the protective immune responses against virus infection

2009 Fiscal Year Final Research Report

• Project/Area Number: 20790365
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Immunology
• Research Institution: Hokkaido University
• Principal Investigator: MORIMOTO Junko Hokkaido University, 遺伝子病制御研究所, 助教 (20451396)
• Project Period (FY): 2008 – 2009
• Keywords: ウイルス / 感染症 / 細胞・組織 / 記憶免疫細胞

Research Abstract

In this study, we found that Opn expression is induced both in the lung and lymphoid tissues such as spleen following influenza A virus infection. Although initial immune responses are comparable between Opn-deficient and Opn-intact mice, Opn-deficient mice maintained more virus-specific memory CD8^+T cells at 60 days after infection. So far, we assume that osteopontin modulates the generation of memory CD8^+T cells following influenza A virus infection through presumably regulating IL-12 production by antigen presenting cells.

Research Products

• [Journal Article] As a Target Molecule for the Treatment of Inflammatory Diseases. (2009)
  • Author(s): Morimoto J, Kon S, Matsui Y, Uede T. Osteopontin
  • Journal Title: Curr. Drug. Tragets
  • Peer Reviewed
• [Journal Article] Regulatory role of DC-derived osteopontin in systemic allergen sensitization. (2009)
  • Author(s): Kurokawa M, Konno S, Takahashi A, Plunkett B, Rittling SR, Matsui Y, Kon S, Morimoto J, Uede T, Matsukura S, Kokubu F, Adachi M, Nishimura M, Huang SK.
  • Journal Title: Eur. J. Immunol 39(12) Pages: 3323-30
  • Peer Reviewed
• [Journal Article] Accelerated development of aging-associated and instanility-induced osteoarthritis in osteopontin-deficinet mice. (2009)
  • Author(s): Matsui Y, Iwasaki N, Kon S, Takahashi D, Morimoto J, Matsui Y, Denhardt DT, Ritting S, Minami A, Uede T.
  • Journal Title: Arthritis Rheum. 60(8) Pages: 2362-71
  • Peer Reviewed
• [Journal Article] Alpha9 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis. (2009)
  • Author(s): Kanayama M, Kurotaki D, Morimoto J, Asano T, Matsui Y, Nakayama Y, Saito Y, Ito K, Kimura C, Iwasaki N, Suzuki K, Harada T, Li HM, Uehara J, Miyazaki T, Minami A, Kon S, Uede T.
  • Journal Title: J. Immunol 182(12) Pages: 8015-25
  • Peer Reviewed
• [Journal Article] The differential amino acid requirement within osteopontin in alpha 4 and alpha9 integrin-mediated cell binding and migration. (2009)
  • Author(s): Ito K, Kon S, Nakayama Y, Kurotaki D, Saito Y, Kanayama M, Kimura C, Diao H, Morimoto J, Matsui Y, Uede T.
  • Journal Title: Matrix Biol. 28(1) Pages: 11-9
  • Peer Reviewed
• [Journal Article] Osteopontin regulates development and function of invariant natural killer T cells. (2008)
  • Author(s): Diao H, Iwabuchi K, Ki L, Onoe K, Van KL, Kon S, Saito Y, Morimoto J, Denhardt DT, Rittling S, Uede T
  • Journal Title: Proc. Natl. Acad. Sci. U. S. A. 105(41) Pages: 15884-9
  • Peer Reviewed
• [Journal Article] Peripheral CD8+ T cell tolerance to self-proteins is regulated proximally at the T cell receptor. (2008)
  • Author(s): Teague RM, Greengerg PD, Fowler C, Huang MZ, Tan X, Morimoto J, Dosett ML, Huseby ES, Ohlen C
  • Journal Title: Immunity 28(5) Pages: 662-74
  • Peer Reviewed
• [Presentation] Osteopontin deficiency promotes secondary immune response to influenza A virus infection, possibly by regulating the maintenance of virus-specific memory CD8+ T cells. (2009)
  • Author(s): Morimoto J, Sato K, Kida H, Miyazaki T, Uede T
  • Organizer: 第39回日本免疫学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 20091202-20091204
• [Presentation] インフルエンザAウイルス感染防御免疫応答におけるOpnの機能解析 (2009)
  • Author(s): 森本純子, 佐藤佳代子, 伊藤甲雄, 中山洋佑, 松井裕, 喜田宏, 宮崎忠昭, 上出利光
  • Organizer: 第9回オステオポンチン研究会
  • Place of Presentation: 札幌
  • Year and Date: 20090912-20090913
• [Presentation] 感染防御免疫応答におけるオステオポンチンの機能 (2008)
  • Author(s): 森本純子, 松井裕, 上出利光
  • Organizer: 3学会合同大会(第37回日本インターフェロン・サイトカイン学会学術集会、第19回日本生体防御学会学術総会、第45回補体シンポジウム)
  • Place of Presentation: 札幌
  • Year and Date: 20080712-20080713
• [Presentation] The interaction of alpha9 integrin with its ligands regulates the development of rheumatoid arthritis. (2008)
  • Author(s): Morimoto J, Kanayama M, Kurotaki D, Asano T, Nakayama Y, Ito K, Saito Y, Kimura C, Harada T, Mei LH, Uehara J, Miyazaki T, Uede T, Kon S.
  • Organizer: 2nd International Conference on Osteoimmunology
  • Place of Presentation: Rhodes, Greece
  • Year and Date: 20080608-20080613
• [Book] 炎症・再生医学事典(オステオポンチン) (2009)
  • Author(s): 森本純子、上出利光
  • Total Pages: 106-108
  • Publisher: 朝倉書店
• [Book] Medical Science Digest(オステオポンチンと自己免疫疾患) (2008)
  • Author(s): 森本純子、上出利光
  • Total Pages: 328-329