2009 Fiscal Year Final Research Report
Regulation of leukocyte trafficking and immune responses by nepmucin
| Project/Area Number |
20790374
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
UMEMOTO Eiji Osaka University, 医学系研究科, 助教 (90452440)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 接着分子 / 免疫学 / 白血球動態 / 免疫応答 |
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| Research Abstract |
Nepmucin is an Ig-domain-containing adhesion molecule expressed in certain types of vascular endothelial cells. We found that nepmucin is localized to interendothelial contacts and mediates homotypic cell adhesion. Nepmucin showed enhanced lymphocyte transendothelial migration by its Ig domain. We also found that nepmucin mediates uptake of apoptotic cells by the interaction of phosphatidylserine, which appears on the outer leaflet of the plasma membrane in apoptotic cells. These results indicate that nepmucin plays multiple physiological roles.
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Research Products
(8 results)
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[Journal Article] Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions2008
Author(s)
Nakasaki T. Tanaka, T. Okudaira, S., Hirosawa, M., Umemoto, E., Otani, K., Jin, S., Bai, Z., Hayasaka, H., Fukui, Y., Aozasa, K., Fujita, N., Tsuruo, T., Ozono, K., Aoki, J., Miyasaka, M.
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Journal Title
Am. J. Pathol 173
Pages: 1566-1576
Peer Reviewed
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