2009 Fiscal Year Final Research Report

Analysis of TCR regulation by a lysosomal protein LAPTM5

Research Project

Project/Area Number	20790382
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Immunology
Research Institution	The Institute of Physical and Chemical Research
Principal Investigator	OUCHIDA Rika The Institute of Physical and Chemical Research, 免疫多様性研究チーム, 研究員 (80391887)
Project Period (FY)	2008 – 2009
Keywords	リソソーム / T細胞抗原受容体 / T細胞活性化 / 自己免疫疾患
Research Abstract	Modulation of surface T cell antigen receptor (TCR) expression is an important mechanism for the regulation of immune responses and the prevention of T cell hyperactivation and autoimmunity. After antigen stimulation, TCR are internalized and degraded in lysosomes. However, few of the molecules involved in this process have been identified. We demonstrate that the lysosomal protein LAPTM5 negatively regulated surface TCR expression by promoting its degradation. These results identify a lysosomal protein illustrate a unique mechanism for the control of surface TCR expression and T cell activation.

(2 results)