2009 Fiscal Year Final Research Report
M cell differentiation based on lympho-epithelial interaction
Project/Area Number |
20790383
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Immunology
|
Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
HASE Koji The Institute of Physical and Chemical Research, 免疫系構築研究チーム, 研究員 (20359714)
|
Project Period (FY) |
2008 – 2009
|
Keywords | M細胞 / パイエル板 / 上皮細胞 / B細胞 / 粘膜免疫 |
Research Abstract |
M cells are developed in a course of cell-cell interaction between FAE and certain unidentified immune cells. We found that a unique B-cell subset characterized by CCR6^<hi>CD11c^+ resided in mouse PP.Adoptive transfer of CCR6^<hi>CD11c^+ B cells from wild-type mice restored the M-cell decrement in CCR6-deficient mice. Collectively, the spatial regulation of CCR6^<hi>CD11c^+ B cells via the CCL20-CCR6 system may play a vital role in M-cell differentiation in mice.
|
-
[Journal Article] Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response.2009
Author(s)
Hase K, Kawano K, Nochi T, Pontes GS, Fukuda S, Ebisawa M, Kadokura K, Tobe T, Fujimura Y, Kawano S, Yabashi A, Waguri S, Nakato G, Kimura S, Murakami T, Iimura M, Hamura K, Fukuoka S, Lowe AW, Itoh K, Kiyono H, Ohno H.
-
Journal Title
Peer Reviewed
-
[Journal Article] M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex.2009
Author(s)
Hase K, Kimura S, Takatsu H, Ohmae M, Kawano S, Kitamura H, Ito M, Watarai H, Hazelett CC, Yeaman C, Ohno H.
-
Journal Title
Nat. Cell Biol. 11
Pages: 1427-32
Peer Reviewed
-
-
-
-
-
[Journal Article] Comprehensive gene expression profiling of Peyer's patch M cells, villous M-like cells, and intestinal epithelial cells.2008
Author(s)
Terahara K, Yoshida M, Igarashi O, Nochi T, Pontes GS, Hase K, Ohno H, Kurokawa S, Mejima M, Takayama N, Yuki Y, Lowe AW, Kiyono H.
-
Journal Title
J. Immunol 180
Pages: 7840-6
Peer Reviewed
-
-
-
-
-
-
-