2010 Fiscal Year Final Research Report
Role of POMC gene expression changes for individual differences in analgesia and susceptibility to dependence
| Project/Area Number |
20790406
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied pharmacology
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
KASAI Shinya Tokyo Metropolitan Organization for Medical Research, 東京都精神医学総合研究所, 研究員 (20399471)
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| Project Period (FY) |
2008 – 2010
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| Keywords | 遺伝子多型 / 個人差 / 鎮痛薬感受性 / プロオピオメラノコルチン遺伝子 |
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| Research Abstract |
In the previous study, a single nucleotide polymorphism (SNP) in the proopiomelanocortin (POMC) gene was identified to be associated with individual differences in opioid analgesia and susceptibility to alcohol dependence. The POMC SNP dose not form linkage disequilibrium block with other polymorphisms, suggesting that the SNP would directly affect on individual differences in analgesia and susceptibility to dependence. The expression vector was constructed with 5' flanking region of the POMC gene including the SNP. The human POMC gene consists of three exons, but effective polymorphisms for allelic imbalance experience (AIE) were identified in the last exon. The expression analyses are now on going, and molecular mechanisms underlying individual differences in opioid sensitivity or susceptibility to dependence would be elucidated by these analyses.
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[Journal Article] Association between OPRM1 gene polymorphisms and fentanyl sensitivity in patients undergoing painful cosmetic surgery.2009
Author(s)
Fukuda K, Hayashida M, Ide S, Saita N, Kokita Y, Kasai S, Nishizawa D, Ogai Y, Hasegawa J, Nagashima M, Tagami M, Komatsu H, Sora I, Koga H, Kaneko Y, Ikeda K
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Journal Title
Peer Reviewed
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[Journal Article] Association between KCNJ6 (GIRK2) gene polymorphisms and postoperative analgesic requirements after major abdominal surgery.2009
Author(s)
Nishizawa D, Nagashima M, Katoh R, Satoh Y, Tagami M, Kasai S, Ogai Y, Han W, Hasegawa J, Shimoyama N, Sora I, Hayashida M, Ikeda K
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Journal Title
Peer Reviewed
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[Journal Article] Analgesic requirements after major abdominal surgery are associated with OPRM1 gene polymorphism genotype and haplotype.2008
Author(s)
Hayashida M, Nagashima M, Satoh Y, Katoh R, Tagami M, Ide S, Kasai S, Nishizawa D, Ogai Y, Hasegawa J, Komatsu H, Sora I, Fukuda K, Koga H, Hanaoka K, Ikeda K
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Journal Title
Pharmacogenomics 9(11)
Pages: 1605-1616
Peer Reviewed
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[Journal Article] Association of morphine-induced antinociception with variations in the 5' flanking and 3' untranslated regions of the mu opioid receptor gene in 10 inbred mouse strains.2008
Author(s)
Shigeta Y, Kasai S, Han W, Hata H, Nishi A, Takamatsu Y, Hagino Y, Yamamoto H, Koide T, Shiroishi T, Kasai K, Tsunashima K, Kato N, Ikeda K
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Journal Title
Pharmacogenet Genomics 18(11)
Pages: 927-936
Peer Reviewed
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[Book] Acute Pain: Cause, Effects and Treatment (Sam D' Alonso, Katherine L. Grasso, ed, Advantage of using wild-derived mouse strains for a variety of pain-related studies: Genetic diversity and new genetic tools)2009
Author(s)
Koide T, Catanesi CI, Nishi A, Shiroishi T, Kasai S, Ikeda K, Takahashi A
Total Pages
79-99
Publisher
Nova Science Publishers
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[Book] Acute Pain: Cause, Effects and Treatment (Sam D' Alonso, Katherine L. Grasso, ed, Association between analgesic requirements after major abdominal surgery and polymorphisms of the opioid metabolism-related gene ABCB1.)2009
Author(s)
Kobayashi D, Nishizawa D, Kasai S, Hasegawa J, Nagashima M, Katoh R, Satoh Y, Tagami M, Hayashida M, Fukuda K, Ikeda K
Total Pages
101-110
Publisher
Nova Science Publishers
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