2009 Fiscal Year Final Research Report
Gene-environment interaction in the genesis of Helicobacter pylori-induced gastric atrophy
| Project/Area Number |
20790422
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Nagoya University |
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Principal Investigator |
HISHIDA Asahi Nagoya University, 大学院・医学系研究科, 研究員 (40447339)
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| Project Period (FY) |
2008 – 2009
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| Keywords | 胃がん / 胃粘膜萎縮 / がん予防 / 遺伝子・環境交互作用 / 遺伝子多型 / ヘリコバクター・ピロリ(ピロリ菌) |
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| Research Abstract |
We confirmed the significant association of PTPN11 G/A polymorphism at intron 3 with the risk of H.pylori-induced gastric atrophy in Japanese, revealed that TLR4+3725 G/C polymorphism, a recently-found polymorphism of TLR4, was associated with the risk of H. pylori-induced severe gastric atrophy in Japanese, and also found the novel association of RUNX3 T/A polymorphism at intron 3 with the risk of H. pylori-induced gastric atrophy in Japanese. We feel convinced that we could provide useful evidence for the prevention of gastric atrophy as a precursor of gastric cancer in Japanese.
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[Journal Article] No association between AICDA 7888 C/T polymorphism, Helicobactor pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese.2010
Author(s)
Hishida A, Matsuo K, Goto Y, Mitsuda Y, Akio Hiraki, Naito M, Wakai K, Tajima K, Hamajima N.
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Journal Title
Gastric Cancer (in press)
Peer Reviewed
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[Journal Article] Toll-like receptor 4 +3725 G/C polymorphism, Helicobacter pylori seropositivity, and the risk of gastric atrophy and gastric cancer in Japanese.2009
Author(s)
Hishida A, Matsuo K, Goto Y, Mitsuda Y, Hiraki A, Naito M, Wakai K, Tajima K, Hamajima N.
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Journal Title
Helicobacter 14
Pages: 47-53
Peer Reviewed
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