2010 Fiscal Year Final Research Report
The effects of nanoparticle-rich diesel exhaust on hepatic PPARα
| Project/Area Number |
20790423
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Nagoya University |
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Principal Investigator |
ITO YUKI Nagoya University, 大学院・医学研究科, 助教 (80452192)
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| Project Period (FY) |
2008 – 2010
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| Keywords | ディーゼル排気ナノ粒子 / ペルオキシゾーム活性化受容体 / 脂質代謝 / 炎症 / 肝臓 / 大気汚染 / 遺伝子改変動物 |
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| Research Abstract |
Diesel exhaust is a main airborne contaminant and includes many nanoparticles. The effects of nanoparticle-rich diesel exhaust (NR-DE) on liver in male rats were investigated in this study. Exposure conditions were chosen according to environmental fate of diesel exhaust. NR-DE at the concentrations near the value of environmental standard for 1 month induced hepatic inflammation which did not persist. It was suggested that the nuclear receptor in the liver played a role in this inflammation.
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