2009 Fiscal Year Final Research Report

Investigation of genetic risk factors for cardiovascular disease in general population.

Research Project

Project/Area Number	20790424
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Hygiene
Research Institution	Shiga University of Medical Science
Principal Investigator	TAKASHIMA Naoyuki Shiga University of Medical Science, 生活習慣病予防センター, 特任助教 (80435883)
Project Period (FY)	2008 – 2009
Keywords	循環器・高血圧 / 分子疫学 / 社会医学
Research Abstract	In the present investigation, we examined the association between genetic factor and risk factors of cardiovascular diseases. Single nucleotide polymorphism (SNP) rs1205 on a CRP gene was reported to be associated with serum hsCRP levels. In this study, we examined a possible association between SNP rs1205 and brachial-ankle pulse wave velocity (baPWV) as a surrogate marker for atherosclerosis, in a Japanese general population. Compared with TT genotype, CC and CT genotype was related to increased hsCRP levels (p=0.004) and decreased baPWV levels (p=0.03), although increased hsCRP levels were associated with increased baPWV levels. Further studies are needed to determine whether C allele of rs1205 on CRP predict are associated with decreased risk of atherogenic vascular change and CVD events.